E toru ngā huarahi whakahihiri i hangaia ai e ngā matū ngā matū i tēnei tau
nā Bethany Halford
NGĀ WHĀNUI KUA WHAKAWHITIA NGĀ HONONGA BIARYL I HANGAIA
Kauwhata e whakaatu ana i te hononga biaryl e whakakorikoria ana e te whākōkī.
Ka whakamahia e ngā matū matū ngā ngota biaryl, e whakaatu ana i ngā rōpū aryl e herea ana tetahi ki tetahi e te hononga kotahi, hei ligands chiral, hei poraka hanga rauemi, me ngā rongoā. Engari ko te hanga i te motika biaryl me ngā tauhohenga whakarewa-whakakorikori, pērā i te Suzuki me te Negishi cross-couplings, he maha ngā mahi hanga hei hanga i ngā hoa hononga. Heoi anō, ka ngoikore ēnei tauhohenga whakarewa-whakakorikori i te wā e hanga ana i ngā biaryl matotoru. I whakaaweawehia e te kaha o ngā whākōkī ki te whakakorikori i ngā tauhohenga, i whakamahia e tētahi rōpū i arahina e Alison RH Narayan o Te Whare Wānanga o Michigan te whanaketanga ā-tikanga hei hanga i tētahi whākōkī cytochrome P450 e hanga ana i tētahi ngota biaryl mā te hononga oxidative o ngā hononga waro-hauwai kakara. Ka moe te whākōkī i ngā ngota kakara hei hanga i tētahi stereoisomer huri noa i tētahi hononga me te hurihanga aukati (e whakaaturia ana). Ki tā ngā kairangahau ka taea e tēnei huarahi biocatalytic te huri hei whakawhiti paraoa-me-pata mō te hanga hononga biaryl (Nature 2022, DOI: 10.1038/s41586-021-04365-7).
TE TUNU MŌ NGĀ AMINE TŪTURU I WHAKATŪPATO KI TE TOTE ITI
E whakaatu ana te kauwhata i tētahi tauhohenga e hanga ana i ngā amine tuatoru mai i ngā amine tuarua.
Ko te whakaranu i ngā whakakorikori konganuku e hiahia ana ki te irahiko me ngā amine whai irahiko ka mate i ngā whakakorikori, nō reira kāore e taea te whakamahi i ngā tauhohenga konganuku hei hanga i ngā amine tuatoru mai i ngā amine tuarua. I kite a M. Christina White me ōna hoa mahi i te Whare Wānanga o Illinois Urbana-Champaign ka taea e rātou te karo i tēnei raruraru mēnā ka tāpirihia he tote ki tā rātou tunu kai. Mā te huri i ngā amine tuarua hei tote ammonium, i kitea e ngā kaimātai matū ka taea e rātou te tauhohe i ēnei matū ki ngā olefin whakamutunga, he waikura, me te whakakorikori palladium sulfoxide hei hanga i ngā amine tuatoru maha me ngā momo rōpū mahi (hei tauira, e whakaaturia ana). I whakamahia e ngā kaimātai matū te tauhohenga hei hanga i ngā rongoā antipsychotic Abilify me Semap, me te huri i ngā rongoā o nāianei ko ngā amine tuarua, pērā i te rongoā antidepressant Prozac, hei amine tuatoru, e whakaatu ana me pēhea e taea ai e ngā kaimātai matū te hanga rongoā hou mai i ngā mea o nāianei (Science 2022, DOI: 10.1126/science.abn8382).
I WHAKAITIA TE WARO O NGĀ AZAARENE
E whakaatu ana te kauwhata i tētahi N-waikura quinoline kua hurihia hei N-acylindole.
I tēnei tau, i tāpirihia e ngā kaimātai matū ki te rārangi o ngā mahi whakatika ngota, arā, ngā tauhohenga e huri ana i ngā matua o ngā ngota matatini. I roto i tētahi tauira, i whakawhanakehia e ngā kairangahau tētahi panonitanga e whakamahi ana i te mārama me te waikawa hei tapahi i tētahi waro kotahi mai i ngā azaarene ono-mema i roto i ngā quinoline N-oxides hei hanga i ngā N-acylindoles me ngā mowhiti rima-mema (e whakaaturia ana te tauira). Ko te tauhohenga, i whakawhanakehia e ngā kaimātai matū i roto i te rōpū a Mark D. Levin i Te Whare Wānanga o Chicago, e ahu mai ana i tētahi tauhohenga i uru ai he rama mercury, e whakaputa ana i ngā roangaru maha o te mārama. I kitea e Levin mā ko te whakamahi i tētahi diode marama-whakaputa e tuku ana i te mārama i te 390 nm i hoatu ki a rātou he mana whakahaere pai ake, ā, i taea ai e rātou te hanga i te tauhohenga whānui mō ngā quinoline N-oxides. Mā te tauhohenga hou ka hoatu ki ngā kaihanga ngota he huarahi ki te whakahou i ngā matua o ngā matū matatini, ā, ka taea te āwhina i ngā kaimātai matū rongoā e rapu ana ki te whakawhānui i ā rātou whare pukapuka o ngā kaitono rongoā (Science 2022, DOI: 10.1126/science.abo4282).
Wā tuku: Hakihea-19-2022